Many people benefit from taking medication for their psychological issues. Best practice guidance sometimes recommends medication and psychological therapy as a combined treatment. However, there have been some recent reports about possible negative effects associated with medications: 1) A pharmacist [here] warns of possible, ‘terrible’ withdrawal symptoms associated with coming off of paroxetine, duloxetine and venlafaxine. 2) The antidepressant amitriptyline causes weight gain, increased heart rate and elevated blood pressure in many [see here]. And 3) Sedating antidepressants such as mirtazapine, amitriptyline and trazodone are sometimes prescribed for sleeplessness but can result in chronic insomnia in the long term [here]. On a positive note, the side effects of thirty antidepressants have been ranked for the first time. There are large differences between them. The ‘take-away’ from this study is that different antidepressants are likely to be appropriate for people with the same diagnosis [see here].